Improvement of Dissolution Properties of Ketoconazole Using a New Excipient (LoxOralTM) in Comparison with Microcrystalline Cellulose
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چکیده
Introduction: Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most pressing problems in pharmaceutical R&D, with as many as 90% of new API candidates in this category (Lobmann et al., 2013). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs (Zimmermann et al., 2009), which may limit their bioavailability after oral administration (Holm et al., 2011).
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Comparison of Dissolution Properties of Piroxicam Using Microcrystalline Cellulose and a New Excipient (LoxOralTM)
Introduction: During the last decade, the trend in drug discovery has increased the number of active pharmaceutical ingredients (APIs) that exhibit high lipophilicity and poor water solubility, also associated with poor dissolution characteristics (Vogt et al., 2008). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs, which ther...
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